Description

Methyl 1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Piperidine-4-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by research institutions, CROs/CDMOs, and pharmaceutical companies engaged in the discovery and development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Key building block for the synthesis of targeted protein kinase inhibitors and other bioactive molecules.
• Critical intermediate in the research and development (R&D) phase of new chemical entities (NCEs).
• Used in Suzuki-Miyaura cross-coupling reactions to introduce the pyrimidine-piperidine scaffold into larger molecular architectures.
• Facilitates structure-activity relationship (SAR) studies during lead optimization in drug discovery programs.
• Employed by contract research and manufacturing organizations (CROs/CDMOs) for custom synthesis and scale-up projects.
• Serves as a reference standard for analytical method development and quality control in API manufacturing.

Basic Information

Item	Details
Product Name	Methyl 1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Piperidine-4-Carboxylate
CAS No.	1160790-50-0
Molecular Formula	C17H26BN3O4
Molecular Weight	347.22 g/mol
Synonyms	Methyl 1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperidine-4-carboxylate; 4-Piperidinecarboxylic acid, 1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, methyl ester; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid methyl ester; CAS 1160790-50-0; Pinacol ester of Methyl 1-(5-boronopyrimidin-2-yl)piperidine-4-carboxylate
EINECS	Contact for details

Quality Control

Every batch of our Methyl 1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Piperidine-4-Carboxylate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles via techniques such as HPLC, NMR, and LC-MS. Our quality commitment ensures material integrity for sensitive pharmaceutical R&D and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.