Description

2-(1H-Imidazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core functionalized with both an imidazole and a pinacol boronate ester group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key boron-containing reagent for constructing C-C bonds in the synthesis of novel drug candidates and complex organic molecules.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of new active ingredients for crop protection products.
• Material Science: Employed in the synthesis of organic electronic materials and functional polymers requiring specific heterocyclic architectures.
• Chemical Biology & Proteomics: Acts as a molecular probe or linker in bioconjugation and target identification studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	2-(1H-Imidazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1160790-26-0
Molecular Formula	C13H17BN4O2
Molecular Weight	272.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1H-imidazol-1-yl)pyrimidine; 2-(Imidazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(1H-Imidazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1160790-26-0; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-imidazol-1-yl-pyrimidine; Boronic acid, B-[2-(1H-imidazol-1-yl)-5-pyrimidinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of 2-(1H-Imidazol-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality protocols include HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your internal quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.