Description

4-Chloro-3,5-Difluorobenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzyl moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: The aldehyde and halogen groups make it a valuable substrate for Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions.
• Organic Synthesis & Research: A versatile reagent for synthesizing heterocycles, ligands, and other complex organic frameworks in academic and industrial R&D.

Basic Information

Product Name	4-Chloro-3,5-Difluorobenzaldehyde
CAS No.	1160573-20-5
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	3,5-Difluoro-4-chlorobenzaldehyde; 4-Chloro-3,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluorobenzaldehyde (primary IUPAC); 3,5-Difluoro-4-chlorobenzaldehyde (alternate IUPAC); Difluorochlorobenzaldehyde; Pharmaceutical Intermediate 1160573-20-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.