Description

4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzenesulfonyl Chloride is a high-value, specialized chemical intermediate featuring a reactive sulfonyl chloride group and a trifluoromethyl-substituted pyrimidine moiety. This compound is critical for researchers and manufacturers requiring precise molecular construction, particularly for introducing specific functional groups into target molecules. It is primarily utilized in the development of advanced pharmaceuticals and agrochemicals, where its unique structure enables the creation of novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and insecticides that leverage the trifluoromethyl group for improved efficacy and environmental profile.
• Material Science: Serves as a precursor for functional polymers and advanced materials requiring specific surface modifications or sulfonamide linkages.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes to study biological systems.
• Custom Synthesis & Contract Manufacturing: Essential for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for client R&D projects.

Basic Information

Product Name	4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzenesulfonyl Chloride
CAS No.	1160058-86-5
Molecular Formula	C11H6ClF3N2O3S
Molecular Weight	338.69 g/mol
Synonyms	4-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)benzenesulfonyl chloride; 2-((4-(Chlorosulfonyl)phenoxy)-4-(trifluoromethyl)pyrimidine; 4-(4-Trifluoromethyl-pyrimidin-2-yloxy)-benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-[[4-(trifluoromethyl)-2-pyrimidinyl]oxy]-; 1160058-86-5
EINECS	Contact for details

Quality Control

Our 4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from moisture, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.