Description

2-Trifluoroacetyl-4-Chloro-5-Hydroxyaniline is a specialized halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoroacetyl and chloro-hydroxy substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a trifluoromethylated aromatic core.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the chloro and trifluoroacetyl groups can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and organic pigments, contributing to color fastness and specific spectral properties.
• Chemical Biology Probe Development: Useful for creating molecular probes and tags due to its reactive amine and hydroxyl groups, which can be selectively modified.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to form complex biaryl structures.

Basic Information

Product Name	2-Trifluoroacetyl-4-Chloro-5-Hydroxyaniline
CAS No.	1159977-60-2
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	4-Chloro-5-hydroxy-2-(trifluoroacetyl)aniline; 5-Amino-2-chloro-4-hydroxy-α,α,α-trifluoroacetophenone; 2-Amino-4-chloro-5-hydroxy-α,α,α-trifluoroacetophenone; 2-Chloro-4-hydroxy-5-amino-α,α,α-trifluoroacetophenone; 1-(2-Amino-4-chloro-5-hydroxyphenyl)-2,2,2-trifluoroethanone; 2-Trifluoroacetyl-5-amino-4-chlorophenol; 4-Chloro-5-hydroxy-2-trifluoroacetylaniline
EINECS	Contact for details

Quality Control

Our 2-Trifluoroacetyl-4-Chloro-5-Hydroxyaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment ensures material integrity for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.