Description

Pyrimidine, 2-Cyclopropyl-4-(4-Piperidinyl)-, Hydrochloride (1:2) is a high-purity, non-nucleoside heterocyclic compound that serves as a critical building block in advanced pharmaceutical research and development. Its molecular architecture, featuring a pyrimidine core with cyclopropyl and piperidinyl substituents, makes it a valuable intermediate for synthesizing novel bioactive molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and testing novel kinase inhibitors.
• Chemical Biology Probes: Utilized in the development of tool compounds for probing biological mechanisms and target validation.
• Process Chemistry: Employed in route scouting and scale-up synthesis for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	Pyrimidine, 2-Cyclopropyl-4-(4-Piperidinyl)-, Hydrochloride (1:2)
CAS No.	1159813-68-9
Molecular Formula	C12H17N3 • 2HCl
Molecular Weight	292.21 g/mol (Free base: 203.28 g/mol)
Synonyms	2-Cyclopropyl-4-(4-piperidinyl)pyrimidine Dihydrochloride; 4-(Piperidin-4-yl)-2-cyclopropylpyrimidine Dihydrochloride; 2-Cyclopropyl-4-piperidin-4-yl-pyrimidine Dihydrochloride; 2-Cyclopropyl-4-(4-piperidyl)pyrimidine Hydrochloride (1:2); UNII-7V2F8P8S1F (component); 1159813-68-9; 2-Cyclopropyl-4-(piperidin-4-yl)pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Pyrimidine, 2-Cyclopropyl-4-(4-Piperidinyl)-, Hydrochloride (1:2) is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring the material is suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.