Description

2-Cyclopropyl-5,6,7,8-Tetrahydro-Pyrido[3,4-D]Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted kinase inhibitors and other small molecule drug candidates.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in early-stage R&D.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for potential commercial API manufacturing.
• Reference Standard: Employed as an analytical standard for method development, quality control, and regulatory submissions.
• Biochemical Research: Utilized in vitro studies to investigate biological pathways and enzyme interactions.

Basic Information

Product Name	2-Cyclopropyl-5,6,7,8-Tetrahydro-Pyrido[3,4-D]Pyrimidine Hydrochloride
CAS No.	1159812-76-6
Molecular Formula	C12H16N3·HCl
Molecular Weight	237.74 g/mol
Synonyms	2-Cyclopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride; 5,6,7,8-Tetrahydro-2-(cyclopropyl)pyrido[3,4-d]pyrimidine hydrochloride; Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-2-cyclopropyl-, hydrochloride; CAS 1159812-76-6
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-5,6,7,8-Tetrahydro-Pyrido[3,4-D]Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.