Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-6-(Pent-4-Ynamido)Hexanoic Acid is a sophisticated, high-purity building block designed for advanced peptide synthesis and bioconjugation research. This compound is a critical reagent for introducing a unique alkyne-functionalized side chain, enabling subsequent "click chemistry" reactions for labeling, cross-linking, or constructing complex biomolecular architectures. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require reliable, high-quality intermediates for creating novel therapeutic candidates and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as a protected, side-chain modified Fmoc-Lysine derivative for the site-specific incorporation of an alkyne handle into peptide sequences.
• Bioconjugation and Labeling: The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for attaching fluorescent dyes, biotin, polyethylene glycol (PEG), or other functional moieties to peptides and proteins.
• Chemical Probe Development: Serves as a key intermediate in synthesizing activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of novel linker-payload systems for targeted cancer therapies by providing a defined chemical handle for conjugation.
• Material Science and Surface Functionalization: Used to create peptide-based coatings or hydrogels with "clickable" sites for further chemical modification of surfaces.
• Library Synthesis for Drug Discovery: Enables the construction of diverse peptide libraries featuring alkyne tags for high-throughput screening and hit identification.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-6-(Pent-4-Ynamido)Hexanoic Acid
CAS No.	1159531-18-6
Molecular Formula	C30H32N2O5
Molecular Weight	500.59 g/mol
Synonyms	Fmoc-Lys(Pentynoyl)-OH; Fmoc-L-ε-pent-4-ynoyl-lysine; Fmoc-Lys(Nε-pent-4-ynoyl)-OH; Nα-Fmoc-Nε-pent-4-ynoyl-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(pent-4-ynamido)hexanoic acid; Fmoc-Lys(Alkyne)-OH; Alkyne-functionalized Fmoc-Lysine derivative; Fmoc-ε-alkyne-L-lysine
EINECS	Contact for details

Quality Control

Our production of (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-6-(Pent-4-Ynamido)Hexanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by titration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.