Description

3-Amino-4-Hydroxyphenylsulphur Pentafluoride is a specialized organofluorine compound featuring a unique pentafluorosulfur (-SF5) functional group. This structural motif is highly valued for its ability to dramatically enhance the metabolic stability, lipophilicity, and overall performance of advanced chemical entities. It serves as a critical building block for researchers and manufacturers developing next-generation materials and bioactive molecules. Primary demand originates from the pharmaceutical, agrochemical, and specialty materials sectors, where its properties enable breakthrough innovations.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the metabolically stable pentafluorosulfur group into novel drug candidates, particularly in medicinal chemistry for CNS, oncology, and antiviral applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the -SF5 group can improve weather resistance and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies, contributing to improved dielectric anisotropy and stability.
• Polymer & Material Science: Employed to create fluorinated monomers and polymers, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in academic and industrial R&D for constructing complex fluorinated aromatic systems.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a building block for creating fluorine-18 labeled radiopharmaceuticals for diagnostic imaging.

Basic Information

Product Name	3-Amino-4-Hydroxyphenylsulphur Pentafluoride
CAS No.	1159512-27-2
Molecular Formula	C6H6F5NOS
Molecular Weight	235.18 g/mol
Synonyms	3-Amino-4-hydroxyphenylsulfur pentafluoride; 4-Amino-3-hydroxyphenylsulfur pentafluoride; (3-Amino-4-hydroxyphenyl)sulfur pentafluoride; 3-Amino-4-hydroxybenzenesulfonyl pentafluoride; SF5-Aniline derivative; 2-Amino-4-(pentafluorosulfanyl)phenol; 4-(Pentafluorosulfanyl)-2-aminophenol; AHPFP
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-4-Hydroxyphenylsulphur Pentafluoride is manufactured and analyzed under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all relevant specifications is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.