Description

(3-Bromo-2,5-Difluorophenyl)Methanol is a versatile fluorinated and brominated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen atoms, which enable selective functionalization for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis, leveraging the benzyl alcohol functionality for complexation.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic core.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	(3-Bromo-2,5-Difluorophenyl)Methanol
CAS No.	1159186-56-7
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	(3-Bromo-2,5-difluorophenyl)methanol; 3-Bromo-2,5-difluorobenzyl alcohol; 2,5-Difluoro-3-bromobenzyl alcohol; 1-(Bromodifluorophenyl)methanol; Benzenemethanol, 3-bromo-2,5-difluoro-; (3-Br-2,5-F2-Ph)CH2OH
EINECS	Contact for details

Quality Control

Our (3-Bromo-2,5-Difluorophenyl)Methanol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality systems are designed to support regulatory filings for our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.