Description

Plazomicin is a next-generation aminoglycoside antibiotic engineered to overcome common resistance mechanisms. Its primary value lies in its potent activity against multidrug-resistant Gram-negative pathogens, including carbapenem-resistant Enterobacteriaceae (CRE). This makes it a critical agent for pharmaceutical R&D and manufacturing, particularly for developing novel antibacterial therapies targeting serious hospital-acquired infections. The compound is identified by CAS No. 1154757-24-0.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable antibiotics for clinical use.
• Antimicrobial Research & Development: Serves as a key reference standard and building block in developing new antibacterial agents and combination therapies.
• Microbiology & Diagnostics: Used in studies to understand bacterial resistance patterns and for susceptibility testing in diagnostic applications.
• Hospital-Acquired Infection Treatment: Targeted for development into drugs treating complicated urinary tract infections (cUTI) and bloodstream infections caused by resistant organisms.
• Reference Standard: Essential for quality control laboratories to perform identity, purity, and potency assays of plazomicin-based drug products.

Basic Information

Product Name	Plazomicin
CAS No.	1154757-24-0
Molecular Formula	C25H48N6O10
Molecular Weight	592.69 g/mol
Synonyms	ACHN-490; ACHN-490 Sulfate; Zemdri; Plazomicin Sulfate; (2S)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-{[(2,2-dimethyl-1-oxopropyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-N5-[(2S)-1-hydroxy-4-methyl-1-oxopentan-2-yl]-2-methylpentanediamide
EINECS	Contact for details

Quality Control

Our Plazomicin is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is tested to ensure high purity and compliance with relevant standards. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, assay, purity, and specified impurities. We support development needs with material suitable for use as a reference standard in analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability and potency. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.