Description

4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary commercial value lies in enabling efficient, high-yield cross-coupling reactions, which are fundamental to constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the aniline and fluorophenyl motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases via Suzuki-Miyaura cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and aniline group contribute to biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for transition metal catalysis and as a precursor for functionalized materials.
• Organic Electronic Materials: Serves as a monomer or intermediate in the synthesis of conjugated polymers and small molecules for OLEDs, OFETs, and other optoelectronic applications.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes, activity-based probes (ABPs), and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1152441-29-6
Molecular Formula	C12H17BFNO2
Molecular Weight	237.08 g/mol
Synonyms	3-Amino-4-fluorophenylboronic acid pinacol ester; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; (3-Amino-4-fluorophenyl)boronic acid pinacol ester; 2-(3-Amino-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-3-(pinacolatoboryl)aniline; 1152441-29-6; 3-Pinacolatoboryl-4-fluoroaniline
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize degradation due to moisture sensitivity and oxidation. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤3.0%
Single Unknown Impurity	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.