Description

1,3-Dimethyluracil-5-Trifluoroborate Potassium Salt is a high-purity organoboron reagent, specifically a potassium trifluoroborate salt derivative of a uracil heterocycle. This compound is valued for its enhanced stability and handling properties compared to traditional boronic acids, making it a critical building block in modern synthetic chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for nucleoside analogs and heterocyclic compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides that require precise heterocyclic frameworks.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boron reagent for palladium-catalyzed carbon-carbon bond formation.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers where the uracil moiety imparts specific properties.
• Bioconjugation & Probe Development: Useful in medicinal chemistry for creating labeled compounds and molecular probes for biological studies.
• Process Chemistry & Scale-up: Suitable for kilogram-scale manufacturing due to its improved stability profile under process conditions.

Basic Information

Product Name	1,3-Dimethyluracil-5-Trifluoroborate Potassium Salt
CAS No.	1150654-77-5
Molecular Formula	C7H9BF3KN2O2
Molecular Weight	248.07 g/mol
Synonyms	Potassium (1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)trifluoroborate; 5-(Trifluoroborato)-1,3-dimethyluracil Potassium Salt; 1,3-Dimethyl-5-(trifluoroboranyl)uracil Potassium Salt; 1,3-Dimethyl-5-trifluoroboraturacil Potassium Salt; 1,3-Dimethyl-5-trifluoroboranyl-2,4(1H,3H)-pyrimidinedione Potassium Salt
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyluracil-5-Trifluoroborate Potassium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B, ¹⁹F), HPLC for purity, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR Purity	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.