Description

2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-8-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its fused quinazoline-dione core structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery programs.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities for various therapeutic targets.
• API Synthesis: Employed in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules for clients.

Basic Information

Item	Detail
Product Name	2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-8-Carbonitrile
CAS No.	1150617-69-8
Molecular Formula	C9H5N3O2
Molecular Weight	187.16 g/mol
Synonyms	8-Cyano-1,2,3,4-tetrahydro-2,4-quinazolinedione; 8-Cyano-3,4-dihydro-2H-quinazoline-2,4-dione; 8-Cyano-1,2,3,4-tetrahydroquinazoline-2,4-dione; Quinazoline-8-carbonitrile, 1,2,3,4-tetrahydro-2,4-dioxo-; 1150617-69-8; 2,4(1H,3H)-Quinazolinedione, 8-cyano-1,2,3,4-tetrahydro-; 8-Cyano-2,4-dihydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-8-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.