Description

(R)-1-(2-(Trifluoromethyl)Pyrimidin-5-Yl)Ethanamine is a high-value, chiral amine building block featuring a pyrimidine core substituted with a trifluoromethyl group. This compound is essential for medicinal chemistry research and development, offering a unique combination of structural motifs that can modulate the pharmacokinetic and binding properties of potential drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drug candidates.
• Kinase Inhibitor Synthesis: Used as a building block for creating potent and selective kinase inhibitors due to the pyrimidine scaffold.
• Agrochemical Research: Employed in the discovery of new herbicides and fungicides where the trifluoromethyl group enhances biological activity.
• Ligand Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential monomer or additive for advanced polymers with specific electronic or surface properties.

Basic Information

Product Name	(R)-1-(2-(Trifluoromethyl)Pyrimidin-5-Yl)Ethanamine
CAS No.	1150263-75-4
Molecular Formula	C7H8F3N3
Molecular Weight	191.16 g/mol
Synonyms	(R)-1-[2-(Trifluoromethyl)pyrimidin-5-yl]ethanamine; (R)-1-(2-(Trifluoromethyl)pyrimidin-5-yl)ethan-1-amine; (R)-α-Methyl-2-(trifluoromethyl)-5-pyrimidinemethanamine; (R)-5-(1-Aminoethyl)-2-(trifluoromethyl)pyrimidine; (R)-2-(Trifluoromethyl)-5-(1-aminoethyl)pyrimidine; (R)-1-(5-Pyrimidinyl)ethylamine, 2-(trifluoromethyl)-; (R)-1-(2-Trifluoromethyl-pyrimidin-5-yl)-ethylamine
EINECS	Contact for details

Quality Control

Our (R)-1-(2-(Trifluoromethyl)Pyrimidin-5-Yl)Ethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure compliance with exacting R&D standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), enantiomeric excess (typically >99% ee), and impurity profile is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.