Description

Ethyl2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4-Methylpyrimidine-5-Carboxylate is a high-value, protected piperazine-pyrimidine hybrid building block. This compound is critical for pharmaceutical research and development, serving as a key synthetic intermediate in the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a defined intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Custom Synthesis: Foundation for the preparation of bespoke, complex molecules for client-specific research and development projects.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for target validation and biological pathway analysis.

Basic Information

Product Name	Ethyl2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4-Methylpyrimidine-5-Carboxylate
CAS No.	1150163-72-6
Molecular Formula	C18H28N4O4
Molecular Weight	364.44 g/mol
Synonyms	Ethyl 2-[4-[(tert-butoxy)carbonyl]piperazin-1-yl]-4-methylpyrimidine-5-carboxylate; 2-(4-Boc-piperazin-1-yl)-4-methyl-pyrimidine-5-carboxylic acid ethyl ester; 1-Boc-4-(5-Ethoxycarbonyl-4-methyl-pyrimidin-2-yl)-piperazine; 1150163-72-6; tert-Butyl 4-(5-(ethoxycarbonyl)-4-methylpyrimidin-2-yl)piperazine-1-carboxylate; Boc-protected pyrimidine-piperazine ester
EINECS	Contact for details

Quality Control

Our Ethyl2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4-Methylpyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.