Description

6-Chloro-2-Phenyl-4-Pyrimidinecarbonyl Chloride is a versatile and highly reactive chemical building block, specifically an acid chloride derivative of a substituted pyrimidine. Its primary value lies in its role as a key synthetic intermediate for constructing complex heterocyclic molecules, enabling the introduction of the 4-pyrimidinecarbonyl moiety. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides that require specific pyrimidine-based structures for activity.
• Material Science Research: Serves as a building block for creating specialized polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based probes (ABPs), and other tools for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	6-Chloro-2-Phenyl-4-Pyrimidinecarbonyl Chloride
CAS No.	1148122-15-9
Molecular Formula	C11H6Cl2N2O
Molecular Weight	253.08 g/mol
Synonyms	4-Pyrimidinecarbonyl chloride, 6-chloro-2-phenyl-; 6-Chloro-2-phenylpyrimidine-4-carbonyl chloride; 2-Phenyl-6-chloropyrimidine-4-carbonyl chloride; 6-Chloro-2-phenyl-4-pyrimidine carboxylic acid chloride; (6-Chloro-2-phenylpyrimidin-4-yl)carbonyl chloride; 6-Chloro-2-phenyl-4-pyrimidinecarbonyl chloride; 1148122-15-9
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-2-Phenyl-4-Pyrimidinecarbonyl Chloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and batch-to-batch consistency, meeting the rigorous standards required for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.