Description

Fmoc-Ile-Ser(Psime,Mepro)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical control over the reactivity of the serine side chain, enabling the precise construction of complex peptides and peptidomimetics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide-based drugs, and biochemical probes. Its high purity and defined structure are essential for ensuring reproducibility in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of protected serine residues into peptide chains.
• Peptidomimetic Research: For the synthesis of modified peptides with enhanced stability, bioavailability, or biological activity.
• Pharmaceutical R&D: In the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new bioactive compounds.
• Bioconjugation: As a precursor for creating peptide conjugates with other molecules like dyes, polymers, or drug carriers.
• Academic Research: For studying protein structure-function relationships, enzyme mechanisms, and molecular recognition processes.

Basic Information

Product Name	Fmoc-Ile-Ser(Psime,Mepro)-Oh
CAS No.	1147996-34-6
Molecular Formula	C27H34N2O7Si
Molecular Weight	526.66 g/mol
Synonyms	Fmoc-Ile-Ser[Psi(Me,Pro)]-OH; Fmoc-Isoleucyl-O-(1-methyl-1-propenyl)-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-O-(1-methyl-1-propenyl)-L-serine; Fmoc-Ile-Ser(ψMe,Pro)-OH; Fmoc-Ile-Ser[Psi(Me,Pro)]-OH; Fmoc-L-Ile-L-Ser(Psime,Mepro)-OH; Pseudoproline dipeptide derivative; Fmoc-protected pseudoproline building block
EINECS	Contact for details

Quality Control

Our Fmoc-Ile-Ser(Psime,Mepro)-Oh is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques to confirm identity and purity. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.