Description

Fmoc-4-Sulfomethyl-Phe(Tce)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its unique sulfomethyl group, which provides enhanced solubility and introduces a reactive handle for further bioconjugation or modification, enabling the creation of complex, functionalized peptides. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide-based drug conjugates, and novel biomaterials. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical research and development applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the incorporation of sulfonated tyrosine analogs into peptide chains, enabling the synthesis of peptides with enhanced aqueous solubility and specific chemical functionality.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, where the sulfomethyl group can be utilized for further derivatization or to improve pharmacokinetic properties.
• Bioconjugation and Linker Chemistry: The reactive sulfomethyl moiety serves as a versatile handle for attaching fluorescent dyes, affinity tags (e.g., biotin), or cytotoxic agents to create targeted drug conjugates.
• Chemical Biology Probes: Essential for synthesizing labeled or modified peptides used as probes to study protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Material Science: Employed in the creation of peptide-based hydrogels, surfaces, or polymers where the introduced chemical group dictates self-assembly or material properties.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the design and synthesis of peptide linkers that connect cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	Fmoc-4-Sulfomethyl-Phe(Tce)-Oh
CAS No.	1146758-11-3
Molecular Formula	C27H23NO8S
Molecular Weight	521.54 g/mol
Synonyms	Fmoc-O-(2,2,2-Trichloroethoxycarbonyl)-L-tyrosine(SO3H); Fmoc-Tyr(SO3H)-Otce; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[(2,2,2-trichloroethoxy)carbonyl]-L-tyrosine, sulfonated; Fmoc-L-Tyr(SO3H)-Otce-OH; Fmoc-Tyr(SO3H)-Tce; (2S)-3-(4-{[(2,2,2-Trichloroethoxy)carbonyl]oxy}-3-sulfophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid; Fmoc-O-Tce-L-Tyrosine(Sulfonic Acid); Fmoc-Tyr(SO3Na)-Otce (sodium salt form)
EINECS	Contact for details

Quality Control

Our Fmoc-4-Sulfomethyl-Phe(Tce)-Oh is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry best practices for advanced pharmaceutical intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.