Description

1-(2-Pyrimidinyl)-3-Piperidinamine (Salt data: 1.95HCl 0.5H2O) is a high-purity, non-racemic organic salt with a defined stoichiometry, serving as a critical building block in advanced chemical synthesis. This compound matters because it provides a reliable and consistent source of a complex amine-pyrimidine pharmacophore, essential for research and development in demanding fields. It is primarily needed by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers for applications such as medicinal chemistry, process development, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined chiral center and complex heterocyclic structure.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with specific biological activity.
• Chemical Biology: Employed as a molecular probe or ligand in biochemical assays and target identification.
• Process Chemistry: Used for scaling up synthetic routes in pilot plants and for manufacturing development batches.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-(2-Pyrimidinyl)-3-Piperidinamine (Salt data: 1.95HCl 0.5H2O)
CAS No.	1146290-25-6
Molecular Formula	C9H15Cl2N4O0.5 (for salt form)
Molecular Weight	~266.15 g/mol (for salt form)
Synonyms	3-Amino-1-(pyrimidin-2-yl)piperidine dihydrochloride hemihydrate; 1-(Pyrimidin-2-yl)piperidin-3-amine hydrochloride hydrate; (R/S)-1-(2-Pyrimidinyl)-3-piperidinamine hydrochloride hydrate; 2-(3-Aminopiperidin-1-yl)pyrimidine hydrochloride; 1146290-25-6; UNII-7V8A6U31QN; 7V8A6U31QN
EINECS	Contact for details

Quality Control

Every batch of 1-(2-Pyrimidinyl)-3-Piperidinamine hydrochloride hydrate is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, which is critical for your research and development continuity. Certificates of Analysis (COA) detailing specifications such as chiral purity, assay, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	2.0% - 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.