Description

n-(3-Acetylphenyl)-4-Oxo-3-Phenyl-3,4-Dihydroquinazoline-7-Carboxamide is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel drug candidates targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential active pharmaceutical ingredients (APIs) for drug discovery programs.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Kinase Inhibitor Development: The quinazolinone structure is a privileged scaffold in the design of inhibitors for various kinase targets involved in oncology and inflammatory diseases.
• Biochemical Probe Synthesis: Employed to create tool compounds for investigating specific enzyme functions and cellular signaling pathways in academic and industrial research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of non-commercial, investigational compounds.

Basic Information

Product Name	n-(3-Acetylphenyl)-4-Oxo-3-Phenyl-3,4-Dihydroquinazoline-7-Carboxamide
CAS No.	1144427-60-0
Molecular Formula	C23H17N3O3
Molecular Weight	383.40 g/mol
Synonyms	N-(3-Acetylphenyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-7-carboxamide; 7-Quinazolinecarboxamide, N-(3-acetylphenyl)-3,4-dihydro-4-oxo-3-phenyl-; 3,4-Dihydro-4-oxo-3-phenyl-N-[3-(acetyl)phenyl]-7-quinazolinecarboxamide; 1144427-60-0; UNII-6M4J4V8Q7K; 6M4J4V8Q7K; AKOS025310957; BDBM50389359; ZINC000003869397; SCHEMBL15445097.
EINECS	Contact for details

Quality Control

Our n-(3-Acetylphenyl)-4-Oxo-3-Phenyl-3,4-Dihydroquinazoline-7-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.