Description

5-Bromo-4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine is a high-value, multi-functional heterocyclic building block critical for advanced organic synthesis. This compound is specifically engineered to serve as a key intermediate in the development of novel pharmaceutical agents and agrochemicals, where its unique halogenated and tosylated structure enables precise molecular modifications. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and specialty chemical producers engaged in medicinal chemistry and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting specific biological pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators, leveraging its halogenated pyrrolopyrimidine core.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and activity-based protein profiling (ABPP) reagents to study enzyme function.
• Material Science: Potential building block for organic electronic materials and advanced polymers due to its conjugated heterocyclic system.
• Academic & Industrial R&D: Enables exploratory synthesis for novel compound libraries in drug discovery and lead optimization programs.

Basic Information

Product Name	5-Bromo-4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1143534-78-4
Molecular Formula	C13H9BrClN3O2S
Molecular Weight	386.65 g/mol
Synonyms	5-Bromo-4-chloro-7-(4-methylphenyl)sulfonyl-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-bromo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-[(4-methylphenyl)sulfonyl]-; 5-Bromo-4-chloro-7-tosylpyrrolo[2,3-d]pyrimidine; 1143534-78-4; 5-Br-4-Cl-7-Ts-7H-Pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP and ISO standards for pharmaceutical and research-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.