Description

(R)-4-Amino-n-(1-(4-Chlorophenyl)-3-Hydroxypropyl)-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a complex chiral structure. This compound is critical for research and development in targeted therapeutic areas, offering a key building block for novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of sophisticated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel small-molecule drugs.
• Kinase Inhibitor Research: Used as a core structural component in the synthesis of potential kinase inhibitors, targeting specific signaling pathways.
• Oncology Drug Discovery: Employed in preclinical studies for developing targeted cancer therapies due to its pyrrolopyrimidine scaffold.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for new chemical entities (NCEs).
• Biochemical Research: Acts as a tool compound or a precursor for probes in studying enzyme function and cellular mechanisms.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	(R)-4-Amino-n-(1-(4-Chlorophenyl)-3-Hydroxypropyl)-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamide
CAS No.	1143532-51-7
Molecular Formula	C22H27ClN6O2
Molecular Weight	442.94 g/mol
Synonyms	(R)-4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[1-(4-chlorophenyl)-3-hydroxypropyl]piperidine-4-carboxamide; UNII-2X9Q6SAG1C; 2X9Q6SAG1C; (R)-PF-06447475; PF-06447475 (R-enantiomer); (R)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide; (4R)-4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[(1R)-1-(4-chlorophenyl)-3-hydroxypropyl]piperidine-4-carboxamide
EINECS	Contact for details

Quality Control

Our (R)-4-Amino-n-(1-(4-Chlorophenyl)-3-Hydroxypropyl)-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.