Description

2-Amino-4-(n-Boc-Piperidin-3-Yl)Pyrimidine is a high-purity, protected heterocyclic building block of significant importance in modern organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the discovery and development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR) in lead optimization programs.
• Process Chemistry & Scale-Up: Used in route scouting and process development for the efficient, scalable synthesis of advanced intermediates.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the synthesis of heterobifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for clients.

Basic Information

Product Name	2-Amino-4-(n-Boc-Piperidin-3-Yl)Pyrimidine
CAS No.	1142953-32-9
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	2-Amino-4-(3-Boc-piperidin-4-yl)pyrimidine; 4-(1-tert-Butoxycarbonylpiperidin-3-yl)-2-pyrimidinamine; 2-Amino-4-(1-(tert-butoxycarbonyl)piperidin-3-yl)pyrimidine; tert-Butyl 3-(2-aminopyrimidin-4-yl)piperidine-1-carboxylate; 2-Amino-4-(N-Boc-piperidin-3-yl)pyrimidine; 2-Amino-4-(1-Boc-3-piperidyl)pyrimidine; 2-Amino-4-(3-piperidyl)pyrimidine, N-Boc protected; CAS 1142953-32-9
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(n-Boc-Piperidin-3-Yl)Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards of pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines and can provide material suitable for use under GMP conditions for non-clinical studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.