Description

2-Pyrimidinamine, 4-Chloro-5-Methyl-n-[4-[2-(1-Pyrrolidinyl)Ethoxy]Phenyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing innovative small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Oncology Research: Used in the development of targeted cancer therapies, including kinase inhibitors, due to its pyrimidine-based scaffold.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Biochemical Research: Acts as a tool compound or a ligand in biochemical assays and high-throughput screening (HTS) campaigns.
• Custom Synthesis: Provided to contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.
• Academic Research: Supplied to university laboratories for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	2-Pyrimidinamine, 4-Chloro-5-Methyl-n-[4-[2-(1-Pyrrolidinyl)Ethoxy]Phenyl]-
CAS No.	1138473-55-8
Molecular Formula	C17H21ClN4O
Molecular Weight	332.83 g/mol
Synonyms	4-Chloro-5-methyl-N-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]pyrimidin-2-amine; 4-Chloro-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidin-2-amine; UNII-6K8V7EZO2S; 6K8V7EZO2S; 4-Chloro-5-methyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-pyrimidinamine; 2-Pyrimidinamine, 4-chloro-5-methyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with the stringent requirements of pharmaceutical development. Our commitment to cGMP principles and analytical rigor guarantees a reliable and consistent supply for critical research and pre-clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.