Description

Fmoc-Arg(Me,Pbf)-Oh CAS NO 1135616-49-7 is a protected derivative of arginine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of modified arginine residues, enabling the synthesis of complex peptides with high precision and purity. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptide chains on resin.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Peptidomimetic Synthesis: Enables the creation of modified peptide structures with enhanced stability and biological activity.
• Bioconjugation and Labeling: Serves as a precursor for introducing arginine derivatives into biomolecules for diagnostic or targeting purposes.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and enzyme mechanisms.
• High-Purity Reference Standard: Used as a certified reference material for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	Fmoc-Arg(Me,Pbf)-Oh
CAS No.	1135616-49-7
Molecular Formula	C33H45N5O7S
Molecular Weight	655.81 g/mol
Synonyms	Fmoc-NG-Methyl-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)arginine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-NG-methyl-NG-[(2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl]-L-arginine; Fmoc-Arg(Me,Pbf)-OH; Fmoc-NG-methyl-NG-(Pbf)-L-arginine; Fmoc-NG-Methyl-NG-(pentamethyldihydrobenzofuransulfonyl)arginine; Fmoc-L-Arg(Me,Pbf)-OH; (2S)-5-[[(2,2,4,6,7-Pentamethyldihydrobenzofuran-5-yl)sulfonyl](methyl)amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Me,Pbf)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.