Description

tert-Butyl 4-(4-cyano-2-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Serves as a key intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• API Synthesis: Incorporated into the final synthetic steps for producing target active pharmaceutical ingredients requiring its specific pyrimidine and piperazine motifs.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or conjugates for biochemical and pharmacological studies due to its functional groups.

Basic Information

Product Name	tert-Butyl 4-(4-Cyano-2-Pyrimidinyl)Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	1135283-51-0
Molecular Formula	C14H19N5O2
Molecular Weight	289.34 g/mol
Synonyms	1-Boc-4-(4-cyano-2-pyrimidinyl)piperazine; tert-Butyl 4-(4-cyano-2-pyrimidinyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(4-cyano-2-pyrimidinyl)piperazine; 4-(4-Cyano-2-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester; BOC-4-(4-Cyano-2-pyrimidinyl)piperazine; 1135283-51-0; 4-(4-Cyanopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-cyano-2-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere when appropriate for prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.