Description

5-Bromo-2-Ethynylpyrimidine is a high-purity, versatile pyrimidine derivative featuring both bromo and ethynyl functional groups, making it a critical building block for advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular architecture in complex chemical processes. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients and in academic research for creating specialized ligands and materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, particularly kinase inhibitors and other biologically active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides by serving as a core heterocyclic scaffold.
• Material Science: Acts as a monomer or cross-linking agent in the creation of advanced polymers and functional materials due to its reactive ethynyl group.
• Chemical Synthesis: Employed in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to construct complex molecular frameworks.
• Ligand Synthesis: Useful for preparing novel ligands for catalysis and metal-organic frameworks (MOFs).
• Life Sciences Research: Serves as a biochemical probe or a tagged molecule in proteomics and diagnostic assay development.

Basic Information

Product Name	5-Bromo-2-Ethynylpyrimidine
CAS No.	1135283-08-7
Molecular Formula	C6H3BrN2
Molecular Weight	183.01 g/mol
Synonyms	2-Ethynyl-5-bromopyrimidine; 5-Bromo-2-ethynyl-pyrimidine; Pyrimidine, 5-bromo-2-ethynyl-; 2-(Bromo)ethynylpyrimidine; 5-Bromo-2-ethinylpyrimidine (German); 1135283-08-7 (CAS); 5-Bromo-2-ethynylpyridine (common misnomer)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Ethynylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.