Description

Boc-D-Threo-3-(3-Trifluoromethylphenyl)Serine is a high-purity, non-natural amino acid derivative featuring a Boc-protected amino group and a trifluoromethylphenyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex peptides and peptidomimetics with enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel therapeutic agents, including protease inhibitors and targeted biologics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a non-natural, sterically defined serine analog into peptide chains.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology & Probe Design: Employed in the development of activity-based probes and molecular tools for studying biological pathways.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale manufacturing of peptide-based therapeutics.
• Academic Research: A valuable reagent for universities and research institutes studying peptide structure-activity relationships and drug discovery.

Basic Information

Product Name	Boc-D-Threo-3-(3-Trifluoromethylphenyl)Serine
CAS No.	1134411-38-3
Molecular Formula	C15H18F3NO5
Molecular Weight	349.30 g/mol
Synonyms	(2R,3S)-2-{[(tert-Butoxy)carbonyl]amino}-3-hydroxy-3-[3-(trifluoromethyl)phenyl]propanoic acid; N-(tert-Butoxycarbonyl)-D-threo-3-(3-trifluoromethylphenyl)serine; Boc-D-threo-β-(3-Trifluoromethylphenyl)serine; N-Boc-D-threo-3-(3-Trifluoromethylphenyl)serine; tert-Butyl ((2R,3S)-3-hydroxy-1-oxo-1-(3-(trifluoromethyl)phenyl)propan-2-yl)carbamate; Boc-D-TfmPhe(3)-Ser-OH; Boc-D-3-(3-CF3-Ph)Ser-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Threo-3-(3-Trifluoromethylphenyl)Serine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.