Description

2-Fluoro-4-Phenoxybenzaldehyde is a high-purity fluorinated aromatic aldehyde building block, essential for advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a phenoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved display performance.
• Polymer Modification: Employed to introduce fluorine and aldehyde functionalities into polymer backbones, altering material properties like chemical resistance, thermal stability, and surface energy.
• Cross-Coupling Reactions: The aldehyde group is a versatile handle for further functionalization via reactions like Suzuki-Miyaura or reductive amination, enabling rapid library synthesis for screening.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the development of novel heterocyclic compounds.

Basic Information

Product Name	2-Fluoro-4-Phenoxybenzaldehyde
CAS No.	1133065-51-6
Molecular Formula	C₁₃H₉FO₂
Molecular Weight	216.21 g/mol
Synonyms	4-Phenoxy-2-fluorobenzaldehyde; 2-Fluoro-4-phenoxybenzaldehyde; Benzaldehyde, 2-fluoro-4-phenoxy-; 2-Fluoro-4-(phenoxy)benzaldehyde; (2-Fluoro-4-phenoxyphenyl)methanal
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Phenoxybenzaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of related substances. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, and impurity profiles. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.