Description

(2R,3R)-Fmoc-3-F-3-Phenylpropanoic Acid is a high-purity, non-natural amino acid derivative featuring a fluorine atom at the β-carbon position. This compound is a critical chiral building block for the synthesis of fluorinated peptides and peptidomimetics, enabling the modulation of biological activity, metabolic stability, and conformational properties. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology industries for drug discovery and development programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected fluorinated amino acid for the automated synthesis of fluorinated peptide libraries.
• Peptidomimetic Drug Discovery: Incorporation into novel drug candidates to enhance binding affinity, proteolytic stability, and membrane permeability.
• Chemical Biology Probes: Synthesis of activity-based probes and fluorinated substrates for studying enzyme mechanisms and protein-protein interactions.
• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex fluorinated active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: For structure-activity relationship (SAR) studies to explore the effects of β-fluorination on peptide backbone conformation and bioactivity.

Basic Information

Product Name	(2R,3R)-Fmoc-3-F-3-Phenylpropanoic Acid
CAS No.	1132645-30-7
Molecular Formula	C24H19FNO4
Molecular Weight	404.41 g/mol
Synonyms	Fmoc-(2R,3R)-3-Fluoro-3-phenylalanine; (2R,3R)-3-Fluoro-3-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-D-β-phenylalanine; Fmoc-D-3-F-β-Hph-OH; (2R,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-fluoro-3-phenylpropanoic acid; Fmoc-(2R,3R)-β-Fluoro-β-phenylalanine
EINECS	Contact for details

Quality Control

Our (2R,3R)-Fmoc-3-F-3-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.