Description

Ticagrelor is a potent, direct-acting, and reversibly binding P2Y12 receptor antagonist, classified as a cyclopentyltriazolopyrimidine (CPTP) antiplatelet agent. It is a critical active pharmaceutical ingredient (API) used in the prevention of atherothrombotic events, such as heart attack and stroke, in patients with acute coronary syndrome (ACS). This high-purity compound is essential for pharmaceutical manufacturers engaged in the production of finished dosage forms, primarily oral tablets, for the global cardiovascular therapeutics market.

Application

• Primary Pharmaceutical Ingredient: Core active component in the formulation of antiplatelet medications (e.g., Brilinta®/Brilique®).
• Cardiovascular Drug Manufacturing: Used in the production of solid oral dosage forms (tablets) for the treatment of Acute Coronary Syndrome (ACS).
• Prevention of Thrombotic Events: Key API in drugs aimed at reducing the rate of cardiovascular death, myocardial infarction, and stroke.
• Pharmaceutical Research & Development (R&D): Serves as a reference standard and starting material for new drug development and clinical studies.
• Generic Drug Production: Essential for manufacturers developing bioequivalent versions of originator antiplatelet drugs.
• Analytical Testing: Used as a high-purity standard in quality control laboratories for HPLC, dissolution, and assay method development.

Basic Information

Product Name	Ticagrelor
CAS No.	1129683-88-0
Molecular Formula	C23H28F2N6O4S
Molecular Weight	522.57 g/mol
Synonyms	(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; AZD6140; Brilinta (Trade Name); Brilique (Trade Name); Ticagrelorum; Ticagrelor API
EINECS	Contact for details

Quality Control

Our Ticagrelor is manufactured under strict quality management systems in compliance with current Good Manufacturing Practices (cGMP). Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters including assay, related substances, residual solvents, and microbiological quality. We support regulatory filings with DMF/CEP documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.15% Total impurities: NMT 0.5%
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.