Description

Hypocretin (70-98) (Human) is a synthetic peptide fragment corresponding to a key segment of the human orexin neuropeptide. This high-purity reference standard is critical for neurological and metabolic research, enabling precise study of orexin receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on sleep disorders, narcolepsy, and energy homeostasis.

Application

• Neuroscience Research: As a specific ligand for studying orexin receptor (OX1R and OX2R) binding affinity, selectivity, and downstream signaling cascades in vitro.
• Pharmacological Assay Development: Serving as a reference standard in high-throughput screening (HTS) campaigns to identify novel agonists or antagonists for therapeutic development.
• Biomarker & Diagnostic Studies: Use in immunoassay development and validation for detecting orexin-related peptides in biological fluids for clinical research.
• Academic & Pre-clinical Studies: Investigating the role of the orexin system in sleep/wake regulation, appetite, addiction, and stress responses using animal models.
• Quality Control Reference: Acting as a system suitability standard in analytical methods (e.g., HPLC, LC-MS) for characterizing larger orexin peptides or related formulations.

Basic Information

Product Name	Hypocretin (70-98) (Human)
CAS No.	1129545-33-0
Molecular Formula	C142H231N47O43S2
Molecular Weight	3228.8 g/mol
Synonyms	Orexin (70-98) (human); Prepro-orexin (70-98); HCRT (70-98); Hypocretin-1 (human fragment); Orexin-A (human fragment); Orexin neuropeptide precursor (70-98); Orexigenic neuropeptide fragment
EINECS	Contact for details

Quality Control

Every batch of Hypocretin (70-98) (Human) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards for research-grade peptides, including comprehensive characterization by HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific results is available for each shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.