Description

3-Fluoro-N,n-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a unique combination of a protected aniline and a pinacol boronate ester. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex, fluorinated bioactive molecules. The CAS number for this compound is 1129542-03-5.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group serves as a versatile handle for forming carbon-carbon bonds with aryl/heteroaryl halides, enabling rapid diversification of molecular scaffolds.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and insecticides that incorporate fluorinated aniline motifs for enhanced efficacy and environmental profile.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs, where the fluorine atom and boronate can tune electronic properties.
• Ligand and Catalyst Development: The dimethylamino group can act as a weak coordinating site or be further modified to create novel ligands for transition metal catalysis.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of biological molecules to study metabolic pathways and protein-ligand interactions.

Basic Information

Product Name	3-Fluoro-N,n-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1129542-03-5
Molecular Formula	C14H21BFNO2
Molecular Weight	265.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluoro-N,N-dimethylaniline; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-dimethylaniline; 3-Fluoro-N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; N,N-Dimethyl-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Fluoro-5-(pinacolatoboryl)-N,N-dimethylaniline; Boronic acid, B-[3-(dimethylamino)-5-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; CAS 1129542-03-5
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-N,n-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.