Description

Nalpha-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-Nepsilon-Tetradecanoyl-L-Lysine is a specialized, protected amino acid derivative designed for advanced peptide synthesis and biochemical research. This compound is critical for researchers and manufacturers requiring precise control over lysine side-chain modification, enabling the development of complex peptides with tailored lipophilicity and bioactivity. It is primarily utilized in pharmaceutical R&D, proteomics, and the production of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing a myristoyl (tetradecanoyl) group onto the ε-amino group of lysine residues during Fmoc-based synthesis protocols.
• Lipopeptide Development: For the creation of lipopeptides with enhanced membrane permeability, cellular uptake, or anchoring properties for vaccine and drug delivery systems.
• Bioconjugation and Protein Labeling: Serves as a precursor for generating site-specifically lipidated proteins or antibodies for diagnostic and therapeutic applications.
• Chemical Biology Probes: Used in the synthesis of activity-based probes or affinity tags to study protein lipidation, trafficking, and protein-protein interactions.
• Pharmaceutical Intermediate: An essential intermediate in the research and development of novel peptide-based therapeutics targeting metabolic disorders, oncology, and infectious diseases.

Basic Information

Product Name	Nalpha-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-Nepsilon-Tetradecanoyl-L-Lysine
CAS No.	1128181-23-6
Molecular Formula	C35H48N2O6
Molecular Weight	592.77 g/mol
Synonyms	Fmoc-Lys(Myr)-OH; Fmoc-Lys(Tetradecanoyl)-OH; Nα-Fmoc-Nε-tetradecanoyl-L-lysine; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-myristoyl-L-lysine; Fmoc-Lys(Myristoyl)-OH; Fmoc-Lys(C14:0)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(tetradecanamido)hexanoic acid; Fmoc-Lys(C14)-OH
EINECS	Contact for details

Quality Control

Our Nalpha-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-Nepsilon-Tetradecanoyl-L-Lysine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent analytical protocols, ensuring the product meets the exacting standards required for peptide synthesis and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.