Description

Fmoc-L-Lys(Octanoyl)-Oh is a protected amino acid derivative, specifically an Fmoc-L-lysine residue modified with an octanoyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of lipophilic, long-chain fatty acid modifications into peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptide-based vaccines, and novel bioconjugates where enhanced membrane permeability or altered pharmacokinetic properties are desired.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Lipopeptide Development: For constructing peptide antigens and vaccine candidates with integrated lipid chains to improve immunogenicity.
• Therapeutic Peptide Modification: To introduce fatty acid chains (e.g., octanoylation) into peptide drugs to enhance stability, prolong half-life, and improve cell penetration.
• Bioconjugation and Linker Chemistry: Serves as a versatile intermediate for creating peptide-drug conjugates or attaching peptides to other molecules via its reactive carboxyl group.
• Academic and Industrial Research: Used in R&D for studying structure-activity relationships (SAR) and the effects of lipidation on peptide function.
• Production of Antimicrobial Peptides (AMPs): For synthesizing novel lipopeptide analogs with potential antimicrobial activity.

Basic Information

Product Name	Fmoc-L-Lys(Octanoyl)-Oh
CAS No.	1128181-16-7
Molecular Formula	C₃₂H₄₂N₂O₆
Molecular Weight	550.69 g/mol
Synonyms	Fmoc-Lys(Octanoyl)-OH; N6-Octanoyl-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine; Fmoc-L-Lysine(N6-octanoyl)-OH; Nα-Fmoc-Nε-octanoyl-L-lysine; Fmoc-Lys(Oct)-OH; (2S)-6-Octanamido-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid; Fmoc-Lys(C8:0)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Lys(Octanoyl)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.