Description

Fmoc-Ser(Tbu)-Bt CAS NO 1126433-40-6 is a protected amino acid derivative, specifically an Fmoc-serine derivative with a tert-butyl (Tbu) side-chain protecting group activated as a benzotriazole (Bt) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of serine into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the automated, stepwise assembly of peptide sequences, particularly for introducing serine residues.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a versatile linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: A fundamental tool for studying protein structure-function relationships, peptide mimetics, and chemical biology.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Bt
CAS No.	1126433-40-6
Molecular Formula	C27H25N3O5
Molecular Weight	471.51 g/mol
Synonyms	Fmoc-Ser(O-t-Bu)-OBt; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serine Benzotriazol-1-yl Ester; Fmoc-O-tert-butyl-L-serine benzotriazole ester; 1-({[(9H-Fluoren-9-ylmethoxy)carbonyl][(2S)-3-[(2-methylpropan-2-yl)oxy]-2-hydroxypropyl]amino}carbonyl)-1H-benzotriazole; Fmoc-Ser(tBu)-OBt; Fmoc-L-Serine(O-t-butyl) benzotriazolyl ester; Fmoc-Ser(OtBu)-OBt
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Bt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.