Description

Bivalirudin Trifluoroacetic Acid Salt 2-(4-Bromomethyl)Phenyl Pyridine is a high-purity, non-peptide synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is critical for the synthesis and structural modification of active pharmaceutical ingredients (APIs), particularly in the development of novel anticoagulant and antiplatelet therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on producing sophisticated, target-specific drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel direct thrombin inhibitors and related cardiovascular drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Bioconjugation: The bromomethyl group enables its use in linker chemistry for creating antibody-drug conjugates (ADCs) or other targeted therapeutics.
• Chemical Biology Probes: Utilized in developing molecular probes to study enzyme inhibition mechanisms, particularly for serine proteases.
• Process Development: Employed in scaling up and optimizing synthetic routes for pilot and commercial-scale manufacturing.

Basic Information

Item	Details
Product Name	Bivalirudin Trifluoroacetic Acid Salt 2-(4-Bromomethyl)Phenyl Pyridine
CAS No.	1124915-67-8
Molecular Formula	C46H62BrN9O15 • C2HF3O2 (Contact for exact salt stoichiometry)
Molecular Weight	Contact for details
Synonyms	2-(4-(Bromomethyl)phenyl)pyridine Bivalirudin Trifluoroacetate; Bivalirudin TFA Salt Derivative; Bivalirudin Intermediate with 4-(Bromomethyl)phenylpyridine; (4-(Bromomethyl)phenyl)-2-pyridinyl Bivalirudin Salt; Angiomax® Intermediate Analog; Synthetic Thrombin Inhibitor Intermediate; TFA Salt of Bivalirudin-Pyridine Conjugate
EINECS	Contact for details

Quality Control

Our Bivalirudin Trifluoroacetic Acid Salt 2-(4-Bromomethyl)Phenyl Pyridine is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.