Description

N1-(5-(4-(Difluoromethoxy)Phenyl)Pyrimidin-2-Yl)-4-Methylbenzene-1,3-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly due to the presence of the difluoromethoxy and pyrimidine moieties. It is primarily needed by R&D laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the synthesis of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Kinase Inhibitor Development: Used in the research and development of kinase inhibitors, leveraging the pyrimidine core which is common in many targeted cancer therapies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Chemical Biology Probes: Acts as a precursor for creating chemical probes to study specific biological pathways and target validation.
• Custom Synthesis: Utilized by fine chemical manufacturers for custom synthesis projects requiring high-complexity, multi-step organic transformations.
• Reference Standard: Supplied as a high-purity analytical reference standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	N1-(5-(4-(Difluoromethoxy)Phenyl)Pyrimidin-2-Yl)-4-Methylbenzene-1,3-Diamine
CAS No.	1123515-40-1
Molecular Formula	C19H16F2N4O
Molecular Weight	354.35 g/mol
Synonyms	4-Methyl-N1-[5-[4-(difluoromethoxy)phenyl]pyrimidin-2-yl]benzene-1,3-diamine; 1,3-Benzenediamine, N1-[5-[4-(difluoromethoxy)phenyl]-2-pyrimidinyl]-4-methyl-; 2-[(2-Amino-5-methylphenyl)amino]-5-[4-(difluoromethoxy)phenyl]pyrimidine; N1-(5-(4-(Difluoromethoxy)phenyl)pyrimidin-2-yl)-4-methyl-1,3-benzenediamine; 4-Methyl-N-[5-[4-(difluoromethoxy)phenyl]pyrimidin-2-yl]benzene-1,3-diamine; CAS 1123515-40-1
EINECS	Contact for details

Quality Control

Our N1-(5-(4-(Difluoromethoxy)Phenyl)Pyrimidin-2-Yl)-4-Methylbenzene-1,3-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.