Description

Fmoc-Glu(Otbu)-Phe-Oh is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with precise sequences. It is primarily needed by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected dipeptide for the sequential assembly of longer peptide chains.
• Pharmaceutical Intermediate: In the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serving as a spacer or linker molecule in the creation of peptide-protein or peptide-small molecule conjugates.
• Biochemical Research: For studying enzyme-substrate interactions, receptor binding, and other structure-activity relationship (SAR) studies.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Custom Peptide Service: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Glu(Otbu)-Phe-Oh
CAS No.	1122076-55-4
Molecular Formula	C34H38N2O7
Molecular Weight	586.68 g/mol
Synonyms	Fmoc-Glu(OtBu)-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-tert-butyl ester-L-phenylalanine; Fmoc-L-Glu(OtBu)-L-Phe-OH; Fmoc-Glu(OtBu)-Phe; N-α-Fmoc-L-glutamyl(O-tert-butyl)-L-phenylalanine; Fmoc-Glu(O-tert-butyl)-Phe-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((tert-butoxy)carbonyl)pentanoic acid-(S)-2-amino-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Otbu)-Phe-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20.0° to -25.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.