Description

n-(3-{[(3-Chlorophenyl)Carbonyl](Methyl)Amino}Propyl)-4-Hydroxyquinazoline-2-Carboxamide is a sophisticated quinazoline derivative, a key chemical scaffold in modern pharmaceutical research and development. This compound is valued for its potential as a high-purity intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents. It is primarily targeted at research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in drug discovery programs, particularly those focusing on kinase inhibition and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and biological pathway studies.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to identify and optimize lead molecules.
• Preclinical Research: Utilized in in vitro and in vivo studies to investigate pharmacokinetics, efficacy, and toxicity profiles.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Provides a specialized chemical entity for universities and research institutes exploring new medicinal chemistry avenues.

Basic Information

Product Name	n-(3-{[(3-Chlorophenyl)Carbonyl](Methyl)Amino}Propyl)-4-Hydroxyquinazoline-2-Carboxamide
CAS No.	1119503-80-8
Molecular Formula	C20H19ClN4O3
Molecular Weight	398.84 g/mol
Synonyms	4-Hydroxy-N-[3-[[(3-chlorophenyl)carbonyl](methyl)amino]propyl]quinazoline-2-carboxamide; 4-Hydroxy-N-[3-[methyl(3-chlorobenzoyl)amino]propyl]quinazoline-2-carboxamide; UNII-1J9Q7F1K8F; 1J9Q7F1K8F; CHEMBL3186667; BDBM50157871; AKOS009158950; AS-75911
EINECS	Contact for details

Quality Control

Our n-(3-{[(3-Chlorophenyl)Carbonyl](Methyl)Amino}Propyl)-4-Hydroxyquinazoline-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards. We support cGMP (current Good Manufacturing Practice) principles for API intermediate production upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere. The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.