Description

2,3-Difluoro-5-Nitrophenol is a high-purity fluorinated nitrophenol derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and fluoro substituents on the phenolic ring, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving charge transport, thermal stability, and optical properties in display technologies.
• Polymer & Resin Modifier: Incorporated as a monomer or additive to impart specific characteristics like chemical resistance, low surface energy, or UV stability to high-performance polymers.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the difluoronitrophenol moiety into more complex architectures.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for advanced imaging and coating applications.

Basic Information

Product Name	2,3-Difluoro-5-Nitrophenol
CAS No.	1119455-04-7
Molecular Formula	C6H3F2NO3
Molecular Weight	175.09 g/mol
Synonyms	5-Nitro-2,3-difluorophenol; 2,3-Difluoro-5-nitro-1-phenol; Phenol, 2,3-difluoro-5-nitro-; 2,3-Difluoro-5-hydroxy-nitrobenzene; 1-Hydroxy-2,3-difluoro-5-nitrobenzene; 2,3-Difluoro-5-nitrophenyl alcohol
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Nitrophenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.