Description

Ethyl 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine-piperazine hybrid structure. This compound is of critical importance for research and development chemists seeking to synthesize novel active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by pharmaceutical companies and contract research organizations (CROs) engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization of the pyrimidine core.
• Biochemical Research: Potential use in the development of chemical probes for studying enzyme function and signal transduction pathways.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and production of clinical trial materials.

Basic Information

Product Name	Ethyl 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylate
CAS No.	1116339-74-2
Molecular Formula	C12H18N4O2
Molecular Weight	250.30 g/mol
Synonyms	Ethyl 2-(4-methyl-1-piperazinyl)-5-pyrimidinecarboxylate; 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 2-(4-methyl-1-piperazinyl)-, ethyl ester; Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate; 1116339-74-2; UNII-6Q6Q5Y8Q2F; 6Q6Q5Y8Q2F
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.