Description

2-Bromo-3-(Trifluoromethyl)Benzaldehyde is a versatile and high-value fluorinated aromatic aldehyde building block. This compound is essential for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research, where the introduction of bromine and trifluoromethyl groups is critical for modulating biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers requiring specific halogenated and fluorinated motifs.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-3-(Trifluoromethyl)Benzaldehyde
CAS No.	1114808-95-5
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	3-(Trifluoromethyl)-2-bromobenzaldehyde; 2-Bromo-α,α,α-trifluoro-m-tolualdehyde; Benzaldehyde, 2-bromo-3-(trifluoromethyl)-; 2-Bromo-3-trifluoromethylbenzaldehyde; 2-Bromo-3-(trifluoromethyl)benzenecarboxaldehyde; m-(Trifluoromethyl)-o-bromobenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-(Trifluoromethyl)Benzaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of related substances and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, and impurity profiles. We support development and commercial projects with specifications tailored to meet cGMP, ICH Q7, and relevant pharmacopeial guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.