Description

(3-Formyl-5-(Trifluoromethyl)Phenyl)Boronic Acid Pinacol Ester is a high-value, multifunctional organoboron building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a formyl group and a trifluoromethyl group on a boronic ester scaffold, enabling precise cross-coupling and subsequent functionalization. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those incorporating the metabolically stable trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the unique properties of fluorine enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components, where the boronic ester and aldehyde functionalities allow for modular construction of conjugated systems.
• Chemical Biology Probes: Useful in the design and synthesis of activity-based probes and molecular tags for studying biological processes, leveraging the bioorthogonal reactivity of the formyl group.
• Fluorine Chemistry: An important reagent for introducing the (trifluoromethyl)phenyl moiety into larger molecules, a common pharmacophore in modern medicinal chemistry.

Basic Information

Product Name	(3-Formyl-5-(Trifluoromethyl)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1112209-44-5
Molecular Formula	C₁₄H₁₆BF₃O₃
Molecular Weight	300.09 g/mol
Synonyms	5-Formyl-3-(trifluoromethyl)benzeneboronic acid pinacol ester; (5-Formyl-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; (3-Formyl-5-(trifluoromethyl)phenyl)boronic acid, pinacol ester; (3-Formyl-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-formyl-5-(trifluoromethyl)phenyl)boronate; 3-Formyl-5-trifluoromethylbenzeneboronic acid pinacol ester; B-[3-Formyl-5-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our (3-Formyl-5-(Trifluoromethyl)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.