Description

2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom and aldehyde group impart specific biological activity and metabolic stability.
• Material Science & OLED Development: Precursor for creating fluorinated organic semiconductors, liquid crystals, and light-emitting materials for display technologies.
• Cross-Coupling Reactions: A versatile Suzuki-Miyaura coupling partner for the efficient introduction of the 2-fluoro-3-formylphenyl moiety into complex molecules.
• Chemical Research & Library Synthesis: Enables medicinal chemistry efforts for lead optimization and the generation of diverse compound libraries for high-throughput screening.
• Ligand & Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde
CAS No.	1112209-40-1
Molecular Formula	C₁₃H₁₆BFO₃
Molecular Weight	250.08 g/mol
Synonyms	2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 3-Formyl-2-fluorophenylboronic acid pinacol ester; (2-Fluoro-3-formylphenyl)boronic acid pinacol ester; 2-Fluoro-3-(pinacolatoboryl)benzaldehyde; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarboxaldehyde; 1112209-40-1; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.