Description

Apelin-36 CAS NO 1107672-29-6 is a synthetic peptide hormone, specifically a 36-amino acid fragment of the endogenous apelin protein. This compound is of significant interest for its role as a potent endogenous ligand for the APJ receptor, influencing cardiovascular function, fluid homeostasis, and metabolic processes. It is primarily utilized by researchers and developers in the pharmaceutical and life science sectors for biochemical research, drug discovery, and the development of novel therapeutic agents targeting cardiovascular diseases, diabetes, and obesity.

Application

• Biomedical Research: Fundamental studies on the apelin/APJ signaling pathway, its physiological roles, and implications in disease states.
• Drug Discovery & Development: Serving as a reference standard, lead compound, or pharmacological tool in high-throughput screening and preclinical studies for cardiovascular and metabolic disorders.
• In Vitro & In Vivo Studies: Used in cell-based assays (e.g., receptor binding, signal transduction) and animal models to investigate therapeutic efficacy and mechanisms of action.
• Diagnostic Development: Potential use in the development of assays to measure apelin levels in biological samples for research purposes.
• Peptide Chemistry & Conjugation: As a substrate for chemical modification, labeling (e.g., fluorescent, isotopic), or conjugation to create novel bioprobes.

Basic Information

Product Name	Apelin-36
CAS No.	1107672-29-6
Molecular Formula	C185H294N56O53S
Molecular Weight	~4195.8 g/mol
Synonyms	Apelin-36 (human); Apelin 36; Pyr-apelin-36; Pyr1-Apelin-36; L-Pyroglutamyl-apelin-36; APLN (65-100), human; APJ receptor ligand; UNII-9R5Q9L6K3U
EINECS	Contact for details

Quality Control

Our Apelin-36 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from tests including HPLC purity, MS (Mass Spectrometry) for identity confirmation, amino acid analysis, and endotoxin levels. We adhere to high standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.