Description

Fmoc-2,4-Dichloro-Dl-Phenylalanine is a protected, non-natural amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique 2,4-dichlorophenylalanine moiety into peptide chains, enabling the creation of peptides with enhanced stability, altered binding properties, and specific biological activities. It is an essential building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science, where precise control over peptide structure and function is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides and peptidomimetics.
• Pharmaceutical Research: Incorporation into therapeutic peptide candidates to modulate bioavailability, receptor affinity, and metabolic stability.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used in studying protein-protein interactions and cellular pathways.
• Antibiotic Development: Building block for novel antimicrobial peptides (AMPs) with potential activity against resistant strains.
• Material Science: Precursor for peptide-based polymers and bio-conjugates with specialized surface properties.
• Agrochemical Research: Component in the synthesis of peptide-inspired bioactive compounds for crop protection.

Basic Information

Product Name	Fmoc-2,4-Dichloro-Dl-Phenylalanine
CAS No.	1105045-80-4
Molecular Formula	C24H19Cl2NO4
Molecular Weight	456.32 g/mol
Synonyms	Fmoc-D-2,4-dichlorophenylalanine; Fmoc-L-2,4-dichlorophenylalanine (racemic mixture); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,4-dichloro-DL-phenylalanine; 2,4-Dichloro-DL-phenylalanine, N-Fmoc derivative; Fmoc-2,4-Cl2-Phe-OH; Fmoc-(2,4-diCl)Phe-OH; N-α-Fmoc-2,4-dichlorophenylalanine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,4-dichlorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2,4-Dichloro-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral composition, and impurity profiles are provided with every shipment. We support compliance with cGMP and other relevant regulatory frameworks for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.