Description

2-(4-(Trifluoromethyl)Phenyl)Pyrimidine-5-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine core and trifluoromethylphenyl substituent. This compound is essential for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this privileged scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the pyrimidine moiety.
• Material Science: Serves as a precursor for the synthesis of functionalized organic materials and ligands for metal-organic frameworks (MOFs).
• Chemical Biology: Employed as a probe or linker in the development of chemical tools for studying biological pathways.
• Organic Synthesis: The aldehyde functional group makes it a versatile substrate for further derivatization via condensation, reduction, or nucleophilic addition reactions.

Basic Information

Product Name	2-(4-(Trifluoromethyl)Phenyl)Pyrimidine-5-Carbaldehyde
CAS No.	1102229-83-3
Molecular Formula	C12H7F3N2O
Molecular Weight	252.20 g/mol
Synonyms	5-Formyl-2-[4-(trifluoromethyl)phenyl]pyrimidine; [4-(Trifluoromethyl)phenyl]-5-pyrimidinecarboxaldehyde; 2-(4-Trifluoromethylphenyl)pyrimidine-5-carboxaldehyde; 2-(4-(Trifluoromethyl)phenyl)pyrimidine-5-carbaldehyde; 5-Pyrimidinecarboxaldehyde, 2-[4-(trifluoromethyl)phenyl]-; 2-(alpha,alpha,α-Trifluoro-p-tolyl)pyrimidine-5-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 2-(4-(Trifluoromethyl)Phenyl)Pyrimidine-5-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.