Description

(2,6-Dichloropyrimidin-4-Yl)-(4-Fluorophenyl)Methanone is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated pyrimidine core structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging its heterocyclic structure for biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialized polymers and advanced organic materials.
• Chemical Synthesis: Employed in organic chemistry research for constructing complex molecular architectures via cross-coupling and nucleophilic substitution reactions.
• Bioconjugation: Potential use in creating labeled probes or antibody-drug conjugates (ADCs) due to its reactive chloropyrimidine moiety.

Basic Information

Product Name	(2,6-Dichloropyrimidin-4-Yl)-(4-Fluorophenyl)Methanone
CAS No.	1099597-81-5
Molecular Formula	C11H5Cl2FN2O
Molecular Weight	271.07 g/mol
Synonyms	4-Fluoro-α,α-dichloropyrimidin-4-ylbenzene; 4-(4-Fluorobenzoyl)-2,6-dichloropyrimidine; (4-Fluorophenyl)(2,6-dichloro-4-pyrimidinyl)methanone; 2,6-Dichloro-4-(4-fluorobenzoyl)pyrimidine; (2,6-Dichloro-4-pyrimidinyl)(4-fluorophenyl)methanone; 4-Fluorobenzoyl-2,6-dichloropyrimidine; 4-(4-Fluorobenzoyl)-2,6-dichloropyrimidine
EINECS	Contact for details

Quality Control

Our (2,6-Dichloropyrimidin-4-Yl)-(4-Fluorophenyl)Methanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.